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XaTTa6Дата: Среда, 22.06.2011, 19:05 | Сообщение # 1
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famuyiyaonДата: Четверг, 09.04.2015, 22:01 | Сообщение # 4
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Varenicline (swop name Chantix in the USA and Champix in Canada, Europe and other countries, marketed next to Pfizer, chiefly in the form of varenicline tartrate), is a remedy medication used to consider nicotine addiction. Varenicline is a nicotinic receptor partial agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this admiration it is comparable tocytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a fragmentary agonist it both reduces cravings looking for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms it can work for some patients to skip smoking.
Medical uses
Varenicline is indicated payment smoking cessation. In a 2006 randomized controlled inquisition sponsored through Pfizer, after inseparable year the figure of persistent abstinence was 10% in place of placebo, 15% for bupropion and 23% benefit of varenicline.<> - In a 2009 meta-analysis of 101 studies funded close Pfizer, varenicline was initiate to be more effectual than bupropion (odds correlation 1.40) and NRTs (odds proportion 1.56).<> -
A Cochrane businesslike scrutinize concluded that varenicline improved the good chance of successfully quitting smoking sooner than two- to three-fold conditioned by to pharmacologically unassisted attempts. Varenicline was more serviceable than bupropion in this view but not statistically upper to NRT.<> -
The FDA has approved the ingest of varenicline representing up to twelve weeks. If smoking cessation has been achieved it may be continued for another twelve weeks.<> -
Varenicline has not been tested in those junior to 18 years old or preggers women and thus is not recommended for spurn at near these groups.
Adverse effects
Nausea occurs commonly in people fetching varenicline. Other less well-known side effects classify cephalalgia, fix sleeping, and abnormal dreams. Rare side effects reported sooner than people winning varenicline compared to placebo cover variation in decorum, vomiting,abdominal pain, flatulence, and constipation. In a modern meta-analysis ownership papers by Leung et al., it has been estimated that instead of every five subjects delightful varenicline at sustentation doses (1 mg twice common), there inclination be an experience of nausea, and for the benefit of every 24 and 35 treated subjects, there will-power be an event of constipation and flatulence respectively. Gastrointestinal side-effects are superior factors compromising the compliance of varenicline.<> - <> -
Despair and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline as a service to smoking cessation had experienced various serious side-effects, including suicidal ideation and infrequent suicidal behavior, haphazard behavior, and drowsiness. On February 1, 2008 the FDA issued an alert to fresh clarify its findings, noting that "it appears increasingly plausible that there is an syndicate between Chantix and serious neuropsychiatric symptoms". It is unexplored whether the psychiatric symptoms are linked to the drug or to nicotine withdrawal symptoms,<citation>needed - although not all patients had stopped smoking. The FDA also recommended that condition misery professionals and patients watch for the benefit of behavioral and mood changes.<> - In May 2008, Pfizer updated the aegis news associated with varenicline, noting that "some patients keep reported changes in behavior, arousal, depressed feeling ready, suicidal thoughts or actions."<> -
As of July 1, 2009, the US Food and Narcotic Administration requires Chantix (varenicline) to carry a negro crate tip, the intermediation's strongest cover omen, due to free reports of side effects including depression, suicidal thoughts, and suicidal actions.<> -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
 
KasparMixДата: Четверг, 14.01.2016, 11:10 | Сообщение # 5
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tcsgroupuДата: Вторник, 14.06.2016, 18:01 | Сообщение # 6
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Docetaxel (as generic or underneath the trade name Taxotere) is a clinically traditional anti-mitotic chemotherapy medication (medication which interferes with cubicle allotment). It is worn mainly to the treatment of mamma, ovarian, prostate, and non-small chamber lung cancer.<> - <> - <> - Docetaxel has an FDA approved call for for treatment of patients who possess locally advanced, or metastatic mamma or non small-cell lung cancer who suffer with undergone anthracycline-based chemotherapy and failed to hold back cancer concatenation or relapsed<> - and a European rubber stamp payment licence in hormone-refractory prostate cancer.<> -
According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks approximately settled a ten cycle course, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - Extent the effectiveness of docetaxel versus paclitaxel and other taxanes is undisturbed controversial. A variety of more late-model articles procure build "no evidence that regimens containing docetaxel yield greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week dispensation register utilized to be and is until now considered efficient but new studies are indicating a weekly outline influence be better. A 2010 article in Accepted Clinical Pharmacology states, "weekly government has emerged as the optimal schedule." Docetaxel is marketed worldwide directed the honour Taxotere nearby Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.<citation>
Constitution
Docetaxel is of the chemotherapy pharmaceutical savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Apt to scarcity of paclitaxel, extensive research was carried out foremost to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and gladly available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain as a substitute for of the benzyl amide in paclitaxel. The carbon 10 functioning organize mutation causes docetaxel to be more water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a pale-complexioned authority and is the working ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a only dose Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion case containing 0.9% sodium chloride or 5% glucose for administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to bestow a settling of 10 mg/mL and the required dose is exhausted from this solution. Vials be suffering with an overfill to compensate as a replacement for fluid harm during preparation, foaming, adhesion to vial walls and the deadened volume. 20 mg vials may be stored in the service of 24 months under 25 °C away from understanding and 80 mg vials for 26 months in the same conditions.<> -
Recently Sanofi has got approval for one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion answer is simplified during eliminating the fundamental dilution step. The two-vial and one-vial formulations restrict the same dose pith, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the unchanging drug theme in the selfsame concentration as the already approved two-vial formulation. The in spite of form, quality, and volume of polysorbate 80 are present in the infusion elucidation of both formulations. The only remainder between these two formulations is the sum of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
 
fmyykjgДата: Воскресенье, 17.07.2016, 23:27 | Сообщение # 7
Группа: Гости





Chlorogenic acid (CGA) is a natural chemical compound which is the ester of caffeic acid and (?)-quinic acid. It is an important biosynthetic intermediate.<> - Chlorogenic acid is an important intermediate in lignin biosynthesis. This compound, known as an antioxidant, may also slow the release of glucose into the bloodstream after a meal.<> -
The term chlorogenic acids can also refer to a related family of esters of hydroxycinnamic acids (caffeic acid, ferulic acid and p-coumaric acid) with quinic acid.<> -
Despite the "chloro" of the name, chlorogenic acids contain no chlorine. Instead, the name comes from the Greek ?????????? (light green) and -???????? (a suffix meaning "giving rise to"), because of the green color produced when chlorogenic acids are oxidized
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
 
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